Reaper is the DAW for audio-engineers that is well supported on GNU/Linux.
FL Studio can works well with Wine or VM but its plugins are another story.
A few WebApps worth knowing (might not suit heavy usage):
There is also LMMS but this is more for small hobbyst rather than serious work.
You might wanna try running in a VM or WinBoat and maybe it’s worth asking on the CrossOver forum to see how well things run with CO.



Fedora is known to be a good middle ground, and that’s why Linus Torvalds is running it on its work machine. But Fedora is more GNOME focus, while it does not stop you from using KDE, if you’re on Xubuntu you might want to consider Kubuntu.