Compounds responsible for the aroma of cannabis and many other plants may offer a surprising new way to relieve chronic pain. Researchers found that several cannabis-derived terpenes significantly reduced pain in mouse models of fibromyalgia and post-surgical pain, with one terpene, geraniol, showing especially strong effects. Unlike THC, these compounds are not associated with psychoactive effects, making them a potentially attractive alternative for pain treatment.
  • pomegranatefern@sh.itjust.worksEnglish
    4 days

    Hey, that’s cool! This seems promising for enabling people dealing with chronic pain to have more options for ways to control pain without needing to potentially compromise mental function when they need it. Now to scroll through the comment section to see everyone’s completely reasonable and measured takes.

  • adam_y@lemmy.worldEnglish
    4 days

    I’m going to run with a little cynicism.

    I live somewhere where cannabis is not legal. There’s pressure, sure, but there’s resistance too.

    One of the factors that helped it legalized in western countries like Canada and the US is the notion of health. Pain relief. Treatment for some chronic illnesses.

    That’s cool. But imagine a pharmaceutical company isolates those health things.

    No need to legalized cannabis anymore.

    This stuff supports the anti-lefalisation movement by taking the benefits from it.

    Damned if we want to use if recreationally.

      • Prathas@lemmy.zipEnglish
        3 days

        What happened to them? I really don’t know the history behind these hard drugs.

        • KingGimpicus@sh.itjust.works
          English
          3 days

          They started as medicines and were concentrated, distilled, and extracted to the point where the medicine it became was deadlier than the cure it provided.

          Coca leaves are still consumed medicinally/recreationally in some parts of south america.

          Poppy seeds have a whole history of being abused and weaponized through the silk road.

          Marijuana has faced a similar story, though without the deaths. This hasn’t stopped governments around the world from conflating the deaths caused by other things with the use of medicines that in no way cause death.

          • Lucius_Sweet@lemmy.worldEnglish
            3 days

            I have to point out that in medicine we use the derivatives from cocaine, novacaine, lidocaine, benzocaine etc as potent short/medium term anaesthetics. Drugs like these make dental extractions for example relatively painless today. Pure cocaine was used previously but was far more toxic to the liver and had a much higher incidence of allergic reaction than its modern derivatives.

  • kakler bitmap@lemmy.worldEnglish
    4 days

    Yall are fuckin wierd lol. I absolutely love cannabis, both recreationally and medically. But if there’s an additional choice to isolate the pain relief aspect without the psychoactive effects of THC, that would be amazing as well. It’s not an either/or choice - there are absolutely use cases for both. Regardless, I’m pretty skeptical that terpenes are any more useful for pain control than essential oils are.

    • SaveTheTuaHawk@lemmy.caEnglish
      4 days

      This industry relies on innuendo and bots to fill comments on Reddit, anything but actual clinical trials with placebo controls. Same thing with terpene sleep aids.

    • abc@suppo.fiEnglish
      3 days

      Thing is, this is the strain that’s gonna be legalized if any. So any fun use would still be illegal.

      • velma@sh.itjust.worksEnglish
        4 days

        The states in the US that have already legalized weed are not going to let go of that tax revenue anytime soon.

    • Cam@scribe.disroot.org
      English
      4 days

      If I’m not wrong, essential oils are rich in terpenes and maybe that’s what makes them useful as a pain treatment.

          • Schmoo@slrpnk.netEnglish
            3 days

            You have friends that have made a therapeutic ritual out of using essential oils which helps them only because the placebo effect can be very powerful for pain. Literally anything could stand in for the essential oils. Swap their oil vials out with convincing fakes and they’ll never know the difference because it’s the ritual of smelling and/or applying the oils that’s helping them, not any real physical mechanism of the compounds in the oils interacting with their biology.

    • gemakey@lemmy.worldEnglish
      4 days

      Huh…I’ve always heard “giraffe pussy.” Lol I never thought about it the other way.

    • dil@piefed.zipEnglish
      4 days

      I hate the pain relief/numbing aspect of some strains, it makes me get comfortable in positions that don’t make me feel bad til the nexy day and then I feel bad for a week

    • Dvixen@lemmy.worldEnglish
      4 days

      Maybe you and I can go splits. You can have my share of the stone if I can have the pain relief part.

    • Darkenfolk@sh.itjust.worksEnglish
      4 days

      Call me when they develop weed that gives all the pain and none of the relief!

      Let’s spice things up, russian roulette with weed instead of bullets.

      • MinnesotaGoddam@lemmy.worldEnglish
        4 days

        so they have these gummy bears with a shitton of capsaican, like 9,000,000 scovilles or something. you’re supposed to chew them for 5 minutes, and they say it’s like getting maced in the mouth. maybe a 6/10 of pain or something, it’s intense but it’s over fast. also you can make it easier with milk, that’d probably drop it down to a 4/10 or something. But 5 minutes and it’s over.

        if you want a pain russian roulette, use those.

    • socsa@piefed.socialEnglish
      3 days

      Call me when they invent weed that makes me feel like I’m wearing grade 7 nipple clamps

    • RisingSwell@lemmy.dbzer0.comEnglish
      4 days

      Ngl that just sounds like my normal weed for years. Originally took it for foot pain after work and it did nothing, but I was high as fuck and didn’t care that much

      • TheStaffmaster@lemmy.worldEnglish
        4 days

        that’s kind of how it works though. The first time i took weed I was doing 12 hour shifts in kitchen work, and i noted how it didn’t remove the pain, it just made me stop careing about it.

    • cattywampas@lemmy.worldEnglish
      5 days

      Or because plenty of people want medicine without unwanted side effects.

      • Smaile@lemmy.caEnglish
        5 days

        Yah the mental haze isn’t a fun trap to fall into. (young me as source)

        • lime!@feddit.nuEnglish
          5 days

          codeine is an opiate. you’re not allowed to drive on that.

          • MinnesotaGoddam@lemmy.worldEnglish
            4 days

            let me literally tell you what my pain management MD told me. “Practice doing the sobriety tests on opioids until you can pass” i think i had the worst doctor.

            • lime!@feddit.nuEnglish
              4 days

              and how do you tell if it has? imagine if the standard for alcohol was the same…

              • tabular@lemmy.worldEnglish
                4 days

                If you can drive safely then go ahead but if you’re impaired by too much of anything that you would drive poorly then don’t. I thought this was common sense.

                • lime!@feddit.nuEnglish
                  4 days

                  the uk sticks out in the statistics of legal limits for alcohol in europe at 0.8‰ BAC; most countries are at 0.2 with some having a zero-tolerance policy, because it affects people so differently and it’s hard to tell.

            • cattywampas@lemmy.worldEnglish
              5 days

              “Take opioids instead of non-psychoactive cannabinoids for pain” is a wild take my guy

              • wasabi_noir@lemmy.zipEnglish
                4 days

                I once had a social worker tell me I should stop smoking weed and get on opiates. I told him he could go fuck himself.

              • stylusmobilus@aussie.zoneEnglish
                5 days

                There was an injection of tongue in cheek with the first comment as well, but that seemed to have missed most

                There’s a big difference between one Panadeine forte and the opioids you might be thinking of. Sometimes it’s just a paracetamol

        • terabyterex@lemmy.worldEnglish
          5 days

          i am sure this cannabis is safer than paracetamol or codeine. and there are people who want that

        • Washedupcynic@lemmy.caEnglish
          5 days

          Codeine can still make people sleepy and sluggish. It’s still an opioid that can lead to dependence and withdrawal. It still has negative GI side effects causing constipation. It’s not a good idea for driving while under the influence. If this can help people in pain without side effect that can cause impairment, why not. Getting high off of cannabis can still be allowed.

          • TheStaffmaster@lemmy.worldEnglish
            4 days

            the first time i took Hydrocodone was after I had my wisdom teeth pulled. I slept a full 8 hours, got up, took my next dose, and then proceeded to pass out for ANOTHER full 8 hours. I put two and two together pretty quickly and just decided to deal with the pain.

          • stylusmobilus@aussie.zoneEnglish
            5 days

            I’m not going to argue, really

            I take one if I have to drive and I’m in pain.

            • actionjbone@sh.itjust.worksEnglish
              5 days

              You don’t need to argue. You just need to accept that every time you do that you put your life, and the lives of the people around you, in danger. And that’s simply a fact.

              • stylusmobilus@aussie.zoneEnglish
                5 days

                Yeah look I think there might be a difference between one Panadeine forte and hard core opiates that have people nodding off.

                Certainly, it’s a lot better than vaping two caps before driving and nine times out of ten it’s just a paracetamol anyway

              • Uranium 🟩@sh.itjust.worksEnglish
                4 days

                My friend, in the UK you can literally buy Panadol both with and without codiene over the counter at a pharmacy

                They have said multiple times they use the without for the most part, which is just paracetamol (acetaminophen).

                The UK and elsewhere don’t have the same problem with opiates as the US does.

                It’s not an offense to drive on medications unless it impares you, in effect giving the police reason to stop you from driving if impaired by it and legal means to prosecute you if you cause harm due to the imparement.

                That also means I could drive whilst high from my cannabis prescription if there was no imparement.

                • Jako302@feddit.orgEnglish
                  3 days

                  It’s not an offense to drive on medications unless it impares you

                  Its not that its no offense, you simply can’t be prosecuted if no one knows about it. But that doesn’t equal legal. If you get into an accident and anyone finds out that you took opioide, even just medical painkillers, you will be attributed most of the blame in court.

                  That also means I could drive whilst high from my cannabis prescription if there was no imparement.

                  A prescription only provides defense in court, not an immunity to prosecution. It still is in your responsibility to prove that you weren’t impaired by your medication, which is nearly impossible. If your tolerance is high enough that your reaction time doesn’t decrease, then its nearly useless either way.

            • velma@sh.itjust.worksEnglish
              5 days

              But if you have cannabis without the high, you could use that instead and be safer.

              I’d love to have the option as a medical marijuana user. Not as punishment for having pain, but for having more options.

              • stylusmobilus@aussie.zoneEnglish
                5 days

                Yeah look, I don’t it’s a bad thing at all, I know this would benefit many people

                • velma@sh.itjust.worksEnglish
                  5 days

                  Your parent comment resonated with me, I get that knee jerk reaction about punishing pain. But yeah I can begrudgingly admit that I would use this if it was available for driving and such.

    • homes@piefed.worldEnglish
      5 days

      On one hand, it sounds like Puritanical bullshit, but on the other hand, I’d like the option.

    • CompactFlax@discuss.tchncs.deEnglish
      5 days

      Idk some people like going to work without pain.

      For me cannabis is an incredibly strong depressant. I can feel suicidal for free with pain, thanks.

  • Betch@lemmy.worldEnglish
    4 days

    This is so stupid. Just more pointless research to make you look the wrong way. Like Cannabis is this miracle plant that could offer us things we didn’t have access to before.

    I love Cannabis, she has been one of my best friends for over 25 years but let’s not kid ourselves. These terpenes aren’t unique to Cannabis, you shouldn’t be getting them from Cannabis, you should be getting them from your food.

    Unfortunately the food you are sold is dead and empty. Not only are processed foods stripped of all you actually need to support a healthy body, the fruits and veggies you buy are mostly dead strains that are grown in dead soil. It’s cheaper upfront, but then you have to pay for it in supplements, taxes and hospital bills.

    Geraniol: Citronella, rose, lemongrass

    Linalool: Lavender, mints, citrus, coriander, basil

    Beta-caryophyllene: Black pepper, rosemary, cloves, hops

    Alpha-humulene: Sage, hops, ginseng, ginger, mints

    Terpenes are the key. Spice up your lives.

    • Numenor@lemmy.world
      English
      4 days

      Slam it to the left if you’re havin’ a good time, shake it to the right If ya know that you feel fine

        • G4Z@lemmy.worldEnglish
          3 days

          Man, I always thought that line was a reference to 90’s sci fi show Space above and beyond…

  • kreskin@lemmy.worldEnglish
    4 days

    Because god forbid anyone ever feel a high that doesnt benefit corporate cartels.

    • Axolotl@feddit.itEnglish
      4 days

      I mean, i don’t want to feel high while i try to relieve some pain yk

  • Stupidmanager@lemmy.worldEnglish
    5 days

    I miss my MJ, but it fucks with my heart so it’s a no go for me. It was critical to my recovery after a head on collision and the after effects. Doc was prescribing dilaudid, and that shit is something like sythentic heroin and his nurse i calling like every week to find out why i never filled the rx.

    Nooo thanks. I hope this proves to be viable.